Issue One 2015
2015, Vol. 2, issue 1, (March)
Original Article
Isoprinosine Induces a Rapid Lympho-Mononuclear Response in Adult Participants
Isoprinosine™ is a drug with immunomodulatory and antiviral properties. It exerted beneficial clinical effect in patients with HSV, HZV, HPV, HBV, influenza and subacute sclerosing panencephalitis. We established an elevation of PBMC and absolute number of small and large lymphocytes in adult participants prior and …
read moreAuthors:
Zahariy Krastev; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;Deian Jelev; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Radina Ivanova; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Original Article
Inosine Pranobex (Isoprinosine) – a Potential Adjuvant in the Management of Chronic HBV Infection
After achieving a durable on-treatment virological response with NUC (nucleos(t)ide analogues), adding an immunomodulating agent seems to have beneficial effect on the course of chronic HBV disease. Methods: Nine patients were investigated (5 – HBeAg(-) and 4 – HBeAg(+). All patients achieved durable on-treatment virological …
read moreAuthors:
Zahariy Krastev; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;Nina Nikolova; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Deian Jelev; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Krasimir Antonov; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Lyudmila Mateva; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Original Article
A Study of Radiographic Changes in Endodontically Treated Teeth Restored with Intra-Radicular Posts
The purpose of the study was to evaluate, by examination of periapical radiographs, whether the application of intra-radicular posts in endodontically treated teeth can lead to the development of periapical lesions. A total of 103 panoramic radiographs from 103 patients (263 endodontically treated teeth) from …
read moreAuthors:
Tsvetelina Borisova-Papancheva; Department of Conservative Dentistry and Oral Pathology, Faculty of Dental Medicine, Medical University –Varna, Bulgaria;Vladimir Panov; Department of Conservative Dentistry and Oral Pathology, Faculty of Dental Medicine, Medical University –Varna, Bulgaria;
Original Article
Effect of the Combined Usage of Ceftiofur with Buserelin and Beta-cloprostenol During Puerperium in Dairy Heifers
The aim of this study was to test the effect of combined usage of ceftiofur with beta-cloprostenol and busereline for puerperal endometritis treatment in dairy heifers. The results received suggest that combined usage of ceftiofur with cloprostenol and buserelin successfully treats puerperal endometritis and significantly …
read moreAuthors:
Dimiter Dimitrov; Faculty of Veterinary Medicine, University of Forestry, Sofia, Bulgaria;Case Reports
Safety and Efficacy of Iron Isomaltoside in Two Cases with Liver Cirrhosis and Iron Deficiency Anemia
Anemia of diverse etiology occurs in about 75% of patients with liver cirrhosis. Mucosal injury due to portal hypertension is an underestimated cause of occult bleeding and iron-deficiency anemia. Iron isomaltoside is a parenteral agent with low free-iron toxicity that is used as a short-term …
read moreAuthors:
Liuben Milatchkov; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;Tanya Petkova; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Deian Jelev; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Rosen Nikolov; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Lyudmila Mateva; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Zaharyi Krastev; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Case Reports
Autoimmune Mimicry Face of Wilson’s Disease
Wilson’s disease is an autosomal recessive disorder. It results in the accumulation of copper in the liver, brain, and other organs. An impairment in the biliary excretion process leads to copper accumulation in the liver, which progressively damages the liver, leading to cirrhosis. Wilson’s disease …
read moreAuthors:
Tanya Petcova; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;Krasimir Antonov; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Rosen Nikolov; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Zoia Spasova; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Lyudmila Mateva; University Hospital “St. Ivan Rilski” Sofia, Clinic of Gastroenterology;
Case Reports
Atypical Sarcoidosis or Malignant Disease: Case Report of Sarcoid Abdominal Lypmhadenopathy
Sarcoidosis is a chronic multisystem disease, characterized by the presence of noncaseating epithelioid granulomas. The commonest site of affection are the lungs and the the intrathoracic lymph nodes, seen in 90 % of the patients (1). Involvement of intraabdominal viscera is less frequent, it may …
read moreAuthors:
Vesela Georgieva; Department of Gastroenterology, Multiprofile Hospital for Active Treatment “Medline Clinic”, Plovdiv;Apostol Georgiev; Department of Gastroenterology, Multiprofile Hospital for Active Treatment “Medline Clinic”, Plovdiv;
Daniela Chifchiiska; Department of Pathology, Multiprofile Hospital for Active Treatment “Medline Clinic”, Plovdiv;
Literature Review
Human Papillomaviruses, Herpes Viruses and Oral Neoplasms
Human papillomaviruses constitute the most widely spread sexually transmitted viral infection world-wide. In about 1% of the cases, a continuing HPV infection can lead to the appearance of precancerous conditions. In a subsequent carcinoma progression, different types of cancer can develop – cervical, rectal, penile, …
read moreAuthors:
Assya Krasteva; Department of Oral and Imaging diahnostics, Faculty of Dental medicine, Medical University – Sofia, Bulgaria;Antonia Dobreva; Dental sytdent, Faculty of Dental medicine, Medical University – Sofia, Bulgaria;
Veselin Galabov; Dental sytdent, Faculty of Dental medicine, Medical University – Sofia, Bulgaria;
Anelia Gozeva; Military Hospital, Department of Microbiology and virology, Sofia, Bulgaria;
Clinical Technique
A Novel Direct Technique for Fabrication of Provisional Fixed Partial Denture
The present article introduces a new technique for chairside provisional fixed partial dentures fabrication. The described direct technique is suitable for a fast and relatively easy fabrication of provisional single crowns or small bridges. It does not necessitate any preliminary laboratory stages (such as wax-up …
read moreAuthors:
Ivan Chakalov; Department of Prosthetic Dentistry, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria;Pavlina Ivanova; Dentist with a Private Practice - Sofia, Bulgaria;