Abstract:

Interleukin 1β (IL-1β) is pro-inflammatory cytokines that plays a key role in pathogenesis of periodontal diseases. The aim of the study is to investigate concentration of IL-1β in GCF and saliva in subjects with periodontitis in parallel with radiographic data of bone loss. 24 patients (including 11 men and 13 females), with a mean age of 49.42 (SD±10) and diagnosed with periodontitis have been involved in the study. There is significantly lower mean IL-1β concentrations in GCF in patients with mean BL < 2 mm in dentition in comparison with patients with mean BL ≥ 2 mm in dentition. There is tendency in patients with bone loss on the sites which the GCF was obtained from (BL on GCF sites) < 5 mm, the GCF concentration of IL-1β to be lower than in patients with BL on GCF sites ≥ 5 mm, but without significant difference. Our findings confirm the statement that IL-1β is an inflammatory mediator that could be associated in higher extend with the general reactivity of the host and in lower extent with local inflammation at a particular periodontal site.  The results justifies the correlation of IL-1β levels in GCF with mean bone loss, i.e. severity of periodontitis and provide grounds for further research to validate this cytokine as one of the biomarkers of periodontitis.