Abstract:

Bisphosphonates are highly effective antiresorptive drugs that are used in the treatment of bone metastases in malignancies, Paget’s disease, fibrous dysplasia, osteogenesis imperfecta, osteoporosis. Their usage unfortunately leads to development of avascular osteonecrosis of the jaw which has been recognized as a complication of bisphosphonate use. BAONJ is a multifactorial disease and there are several factors that can affect the development and the outcome of the BAONJ treatment. The aim of the present study is to establish the influence of one of the risk factors – the period of time from of the surgical intervention on the outcome of the treatment of BAONJ

Materials and methods: In the present study, we included 44 patients diagnosed with Bisphosphonate-associated osteonecrosis of the jaw (BAONJ). The treatment methods applied to the patients we studied are surgical, conservative and surgical-conservative methods. The statistical method used is one-dimensional logistic regression which is from the direction of regression analysis.

Results: Our study shows that with the increase of the he period of time from the surgical intervention, the likelihood of disease progression also increases, found in the examination of the patient on the first and on the sixth month after the treatment of BAONJ.

Conclusion: The factor period of time from the surgical intervention can be used as a predictor of the outcome of BAONJ treatment, and with increasing of its value, the likelihood of disease progression increases.

Keywords: osteonecrosis, bisphosphonates, jaw bones