Issue Two 2015
2015, Vol. 2, issue 2, (July)
Effect of three anesthetic protocols on the haematological indices in cats during ovariohysterectomy
The investigation was performed on 21 healthy adult cats in order to evaluate the effects of three anesthetic protocols on haematological indices during the anesthesia, surgery and for a 24-hour post-surgery period. The animals were divided in to three experimental groups (n=7 in each). The first group (Х/К group) was premedicated with 2 mg/kg xylazine i.m., the second group (In group) – with 0.025 mg/kg acepromazine i.m., and the third group (ММ group) – with 0.025 mg/kg acepromazine i.m., 0.4 mg/kg butorphanol i.m. and 0.3 mg/kg metacam s.c. The induction and maintenance of anesthesia in group Х/К was done with 10 mg/kg ketamine i.v., while in the other two groups, induction with done with 5 mg/kg propofol i.v. After intubation, anesthesia was maintained with isoflurane 2.5 vol% in group In and 1.8 vol% in group ММ in oxygen flow 2.0 l/min. Blood samples were collected prior to anesthesia – 0 min and at min 30, 60, 120 and hour 24 after the inception of anesthesia.
A statistically significant reduction in erythrocyte counts, haemoglobin and haematocrit was observed in the three experimental groups immediately after the beginning of anesthesia. Total white blood cells count was also substantially changed, but marked decrease in leukocyte, granulocyte and lymphocyte counts in groups In and X/K were established on min 120, while in group MM – by the 60th min. The three tested anesthetic protocols decreased the studied blood parameters after the beginning of anesthesia, most probably as a result of neuro-hormonal interactions of the anesthetic drugs and the related blood volume redistribution.
Authors:Nadya Zlateva; Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine University of Forestry, “Kliment Ohridski” str., 10 Sofia, 1505, Bulgaria;
Georgi Marinov; Student – 4 th year, Faculty of Veterinary Medicine, University of Forestry;;