Issue Two 2016
2016, Vol. 3, issue 2, (December)
Prevalence of Epstein–Barr virus and cytomegalovirus in Bulgarian dental patients
Epstein–Barr virus and cytomegalovirus are herpesviruses, in which primary infection may be asymptomatic or cause an infectious mononucleosis-like disease. Although the virus typically targets lymphocytes, a particular blood cell involved in the immune response, almost all organ systems can ultimately be affected by EBV infection. Cytomegalovirus is responsible for a significant percentage of asymptomatic viral infections worldwide. It is important that any cell or organ may be infected .
EBV infection is transmitted from person to person by contact with infectious body fluids – saliva, breast milk etc., sexual contact, blood transfusion . CMVC is detected in the saliva of between 11 and 24% of children attending day-care centers .
Transmition of CMV is by body fluids, sexual contact, blood transfusion, during delivery, or organ transplant .
The aim of the present study was to assess the prevalence of EBV virus and CMV in consecutive patients who attend a dental office.
116 concecutive dental patients participated in the study – 35 male and 81 females, with an average age of 49.3 ± sd 13.9. years. All the patients underwent oral examination. The clinical findings were common oral pathology, common superficial oral lesions, without any maxillo-facial malignancy. All the participants had no data of any malignancy in any part of the body.
Elevated IgM antibodies to CMV were detedced in 2.8%. 6% were positive for VCA-IgM antibodies. Positive VCA-IgG was detected in almost 97 % of all tested dental patients and this reveals that the person has a current or recent EBV infection and may have reactivation of EBV.
This is the first report concerning the prevalence of Epstein-Barr virus and cytomegalovirus in Bulgarian dental patients. The majority of dental patients (95%) have a chronic infection of EBV and some of them reactivate the virus. 8% have an acute infection of EBV and 2,8% of CMV. Coinfections of EBV and CMV were not present in our patients.
Authors:Assya Krasteva; Department of Oral and Imaging Diagnostics, Faculty of Dental Medicine, Medical University, Sofia ;
Angelina Kisselova; Clinic of Gastroenterlogy, Sveti Ivan Rilski Hospital, Medical University, Sofia;
Aneta Ivanova; Department of Oral and Imaging Diagnostics, Faculty of Dental Medicine, Medical University, Sofia ;