Issue Two 2017
2017, Vol. 4, issue 2, (October)
Original Article
Clinical, laboratory and ultrasound characteristics of patients with primary hyperparathyroidism with renal involvement
Abstract:
Primary hyperparathyroidism (PHPT) is unregulated hyperproduction of parathyroid hormone (PTH), inadequate to serum calcium levels. High PTH levels are associated with hypercalciemia, hypercalciuria and hyperphosphaturia, increased bone absorbtion with decreased bone mass and density, gastric hyperacidity with the development of peptic ulcers, and tissue deposition of calium phosphate with pancreatitis, nephrocalcinosis and vascular calcifications. The kidney involvement in PHPT is associated with: nephrolithiasis, nephrocalcinosis, chronic renal disease, and renal tubular dysfunction.
We present a series of 12 consecutive patients (4 male and 8 female, mean age 52.8 +/- 15.1 years, range 30-73) with kidney damage due to PHPT, admitted to the Clinic of Nephrology for the period May 2013 – September 2017. All patients had nephrolithiasis or history of nephrolithiasis, and nephrocalcinosis (cortical and/or medullary), with or without other organ involvement related to persistent hypercalciemia.
We discuss the current knowledge on the diagnosis and treatment of renal involvement in PHPT.
Authors:
Milena Nikolova; Clinic of Nephrology, University Hospital Alexandrovska, Medical University, Sofia;;Georgi Ivanov; Clinic of Nephrology, University Hospital Alexandrovska, Medical University, Sofia;;
Tanya Tsocheva; Clinic of Nephrology, University Hospital Alexandrovska, Medical University, Sofia;;
Radina Nikolova; Clinic of Nephrology, University Hospital Alexandrovska, Medical University, Sofia;;
Vladislava Milenova; Clinic of Nephrology, University Hospital Alexandrovska, Medical University, Sofia;;
Rumiana Krasteva; Clinic of Nephrology, University Hospital Alexandrovska, Medical University, Sofia;;
Regina Djerassi; Clinic of Nephrology, University Hospital Alexandrovska, Medical University, Sofia;;
Boris Bogov; Clinic of Nephrology, University Hospital Alexandrovska, Medical University, Sofia;;
Mihail Boyanov; Clinic of Endocrinology, University Hospital Alexandrovska, Medical University, Sofia;;
Yordan Vlahov; Clinic of Endocrinology, University Hospital Sofiamed, Medical Faculty, Sofia University;;
