Abstract:

Periodontitis is a multifactorial disease with episodes of exacerbation and remission, mediated by the immune response of the host. The pathogenesis of the periodontal disease is disturbing the interest of many investigators in order to find the mechanisms accelerating the destructive process. The cytokines are found to be involved in the host response. Recently the single nucleotide polymorphisms are introduced as a marker for different inflammatory, autoimmune and malignant diseases. According to some researches Interleukin-13 single nucleotide polymorphism is considered a risk factor for developing severe periodontitis. Since the genetic predisposition differ between individuals and among different populations studies are aimed at finding a connection relating this cytokine and its genetic polymorphism with the periodontal disease.

Keywords: periodontitis; pathogenesis; Interlekin-13; single nucleotide polymorphism