MedInform

Journal of Medical and Dental Practice

www.medinform.bgISSN 2367-6795

Issue Two 2022

2022, Vol. 9, issue 2, (September)

Publisher: Medinform LTD
ISSN: 2367-6795
Pages: 1455-1518
Date of close: 2022/10/02

Literature Review

Modulation of host response – use in periodontal diseases

Abstract:

The basis of the macroorganism’s reaction is the inflammatory response to the presence of plaque biofilm,
modified by genetic factors (which explains why the rapidly progressive forms of periodontitis have a tendency for
family aggregation), as well as systemic environmental factors (smoking, diabetes, stress).

Periodontal diseases are multifactorial, complex diseases driven by the immuneinflammatory response to
bacterial plaque in susceptible patients. The importance of the body’s response as a determinant in susceptible
patients has led researchers to identify the genetic frequency that characterizes individuals as resistant or
susceptible to the disease. Researchers are also investigating host response modulating therapies (HMTs) aimed
at modifying or reducing the destructive aspects of the immune response so that the immuneinflammatory
response to bacterial plaque is less damaging to the periodontal tissues. As the pharmaceutical industry develops,
HMTs as an adjunctive therapy in periodontal disease will target different aspects of the body’s response.

Keywords: periodontal diseases, host response modulation therapy, immuneinflammatory response

Authors:

Antоaneta Mlachkova; Faculty of Dental Medicine, Department of Periodontology, Medical University, Sofia, Bulgaria; Email this author

Corresponding Author:

Antоaneta Mlachkova; Faculty of Dental Medicine, Department of Periodontology, Medical University, Sofia, Bulgaria; Email this author