Abstract:

This study aimed to evaluate the use of hyaluronic acid in periodontal regenerative procedures for the treatment of angular defects. Data demonstrated it plays a significant role in tissue healing, hydration, and modulation of inflammation. Its ability to inhibit pro-inflammatory cytokines and to support collagen formation makes it a valuable adjunct in periodontal therapy. The research employed a cross-linked hyaluronic gel (hyaDENT BG®) combined with a bovine bone substitute (Bio-Oss® Collagen) to assess clinical and radiographic outcomes. Eight patients with Stage III periodontitis and overall 14 intrabony defects underwent surgical treatment involving flap elevation, root surface decontamination, application of hyaluronic gel, and graft placement. Clinical parameters such as probing pocket depth, clinical attachment loss, and gingival recession were measured before and after treatment. The results demonstrated significant improvements, with pocket depth decreasing from an average of 7.29 mm to 3.07 mm, and attachment gain of 4.36 mm, indicating enhanced periodontal stability. Radiographic assessments revealed a bone fill of 4.43 mm/mean, representing 88.6% defect fill, thereby confirming the regenerative potential of the hyaluronic acid when combined with graft materials. While these findings are promising, the authors emphasize the need for further research to validate these results across diverse clinical conditions and to establish standardized treatment protocols. In conclusion, hyaluronic acid appears to be a promising adjunct in periodontal regeneration due to its biological properties, easy manipulation, safety, and cost-effectiveness.

Keywords: angular defects, bone graft, hyaluronic acid, periodontitis