MedInform

Journal of Medical and Dental Practice

www.medinform.bgISSN 2367-6795

Issue Four 2025

2025, Vol. 12, issue 4

Publisher: Medinform LTD
ISSN: 2367-6795
Pages: 2206-2306
Date of close: 2025/10/01

Case Reports

Malignant Transformation of Oral Leukoplakia After 16 Years: A Case Report and Literature Review

Oral leukoplakia (OL) is the most common oral potentially malignant disorder. Evidence on time to malignant transformation is scarce. A lifelong, time-dependent risk of malignant transformation has been reported. Despite numerous studies of risk factors for shorter time to transformation, there are currently no predictors …

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Authors:

Samuil Dzhenkov ; Department of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University of Sofia, Sofia, Bulgaria: Department of Maxillofacial Surgery, University Hospital "Alexandrovska", Sofia, Bulgaria.;
Konstantin Stamatov ; Department of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University of Sofia, Sofia, Bulgaria: Department of Maxillofacial Surgery, University Hospital "Alexandrovska", Sofia, Bulgaria.;
Pavel Stanimirov ; Department of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Medical University of Sofia, Sofia, Bulgaria: Department of Maxillofacial Surgery, University Hospital "Alexandrovska", Sofia, Bulgaria.;

Short Communication

Once upon a time Radioactive toothpaste!?

We are writing to inform patients and dental practitioners about a somewhat forgotten product, a result of humanity’s ignorance of the harms of some discoveries. Today, radioactive toothpastes are museum rarities and collector’s items. Some tubes of old toothpastes still emit low levels of radiation. …

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Authors:

Elena-Ana Panova; “Prof. Ivan Apostolov” Private Language Upper Secondary School, Sofia, Bulgaria.;
Vladimir Panov; Department of Conservative Dentistry and Oral Pathology, Faculty of dental medicine, Medical University –Varna, Bulgaria.;

Original Article

Isolation and cultivation of dental pulp stem cells from permanent teeth and verification of their identity

Technologies for tissue engineering are applied for the regeneration of dental pulp. They are based on the use of suitable and accessible cellular sources such as mesenchymal stem cells of dental origin. The creation of cell cultures from stem cells from the dental pulp of …

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Authors:

Rositsa Vladova; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria ;
Janet Kirilova; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria ;
Sevda Yancheva; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria ;

Literature Review

Current Trends and Perspectives in the Development of PRF Platelet Concentrates for Vital Pulp Therapy of Reversible Pulpitis

Platelet concentrates derived from autologous blood are used to stimulate tissue regeneration through the controlled release of growth factors and biologically active proteins. These autologous biomaterials provide a natural fibrin matrix containing platelets, leukocytes, and growth factors that are gradually released and support tissue repair …

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Authors:

Janet Kirilova; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, 1000 Sofia, Bulgaria ;
Rositsa Vladova; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, 1000 Sofia, Bulgaria ;
Sevda Yancheva; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, 1000 Sofia, Bulgaria ;

Original Article

Dentists’ Awareness of Vital Pulp Therapy: A Questionnaire-Based Study

Objective. To assess dentists’ awareness and use of vital pulp therapy for managing pulpitis. Materials and Methods. A questionnaire-based survey was conducted among 378 dentists. A bespoke 17-item instrument was used; data were analysed statistically. Results. Eighty-nine percent of respondents reported using vital pulp therapy, …

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Authors:

Rositsa Vladova; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria ;
Janet Kirilova; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria ;

Original Article

Five-Year Clinical Outcomes of Conservative Management in External Cervical Resorption with Pulpal Involvement

Background: External cervical resorption (ECR) with pulpal involvement poses a significant therapeutic challenge due to its asymptomatic progression, complex defect morphology, and risk of structural compromise. Conservative treatment approaches, combining endodontic and restorative protocols, have emerged as viable alternatives to extraction or extensive surgery, particularly …

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Authors:

Angela Gusiyska; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria;

Literature Review

Ozone –mechanism of action, applicationin treatment of Caries lesionsand Endodontics

Ozone therapy is a method used for treatment and prevention across various areas of general and dental medicine. Ozone therapy has a well-substantiated biological mechanism (the Keap1/Nrf2– GSH axis) which, at low, controlled doses, triggers an adaptive antioxidant response and yields antimicrobial, anti-inflammatory, and biostimulatory …

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Authors:

Janet Kirilova; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria;
Rositsa Vladova; Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria;

Literature Review

Contemporary Methods for Diagnosing Early Occlusal Carious Lesions

Early diagnosis of occlusal carious lesions is crucial for preventive and minimally invasive dental care. Accurate diagnosis requires not only recognition of the lesion itself but also contextual evaluation of biological and behavioral determinants influencing the disease process. The visual-tactile method remains the most widely …

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Authors:

Nedana Georgieva ; Department of Pediatric Dentistry, Faculty of Dental Medicine, Medical University of Sofia, Bulgaria;

Original Article

Evaluating the Impact of Different Cleaning Methods on the Water Absorption of “ThermoSens” Denture Base Material

A variety of thermoplastic materials, including “ThermoSens”, a nylon-based denture base material, can be used in the fabrication of removable partial dentures. Assessing the physical properties of these materials is crucial, as they influence not only the aesthetics but also the longevity and functionality of …

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Authors:

Rumen Radev; Department of Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University – Sofia, Bulgaria;
Nikolay Apostolov; Department of Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University – Sofia, Bulgaria;
Zdravka Yaneva; Department of Paediatric Dental Medicine, Faculty of Dental Medicine, Medical University – Sofia, Bulgaria;

Literature Review

Health Literacy and Its Role in Oral Health Promotion: A Review of Contemporary Concepts and Approaches

Health literacy encompasses a set of knowledge, skills, and attitudes that enable individuals to understand, evaluate, and apply health-related information with the aim of improving health status and quality of life. It is recognized as a key social determinant of health and an important instrument …

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Authors:

Zdravka Yaneva; Department of Pediatric Dentistry, Faculty of Dental Medicine, Medical University of Sofia, Bulgaria;
Nedana Georgieva ; Department of Pediatric Dentistry, Faculty of Dental Medicine, Medical University of Sofia, Bulgaria;

Case Reports

Tuberosity Flanged Maxillary Complete Denture for Enlarged Tuberosities. Case Report.

This case report describes a conservative prosthodontic approach for treating enlarged maxillary tuberosities using a flanged complete denture. A 56-year-old edentulous male presented with poor denture retention, instability, and pain during insertion, caused by bilateral hypertrophic tuberosities with pronounced undercuts. Clinical and radiographic examination confirmed …

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Authors:

Alexander Naydenov; Department of Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University of Sofia;
Nikolay Apostolov; Department of Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University of Sofia;
Rumen Radev; Department of Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University of Sofia;

Case Reports

Management of uncomplicated crown fracture of a permanent central incisor – case report

Traumatic dental injuries (TDIs) are highly prevalent among children and adolescents and often involve crown fractures of the maxillary incisors, which represent the most frequent type of trauma in the permanent dentition. Given the potential biological and psychosocial consequences—ranging from pulp necrosis and disturbances in …

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Authors:

Nedana Georgieva; Private Practice; Email this author